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Article

Chromatin accessibility provides a window into the genetic etiology of human brain disease.

Trends in genetics : TIG - 1 Jul 2025

Bendl Jaroslav, Fullard John F, Girdhar Kiran, Dong Pengfei, Kosoy Roman, Zeng Biao, Hoffman Gabriel E, Roussos Panos

Abstract excerpt

Neuropsychiatric and neurodegenerative diseases have a significant genetic component. Risk variants often affect the noncoding genome, altering cis-regulatory elements (CREs) and chromatin structure, ultimately impacting gene expression. Chromatin accessibility profiling methods, especially assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq), have been used to pinpoint...

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PMID: 39855972
DOI: 10.1016/j.tig.2025.01.001
PMCID: PMC12237611

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