Back to search

Article

Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific <i>cis</i> regulatory elements

2022-10-04

Abstract excerpt

<h4>Summary</h4> Cell type-specific transcriptional differences between brain tissues from donors with Alzheimer’s disease (AD) and unaffected controls have been well-documented, but few studies have rigorously interrogated the regulatory mechanisms responsible for these alterations. We performed single nucleus multiomics (snRNA-seq+snATAC-seq) on 105,332 nuclei isolated from cortical tissues from 7 AD and 8 unaf...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e807bc13-8763-5183-b899-18e9a0b05dc4
DOI
10.1101/2022.10.04.510636
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific <i>cis</i> regulatory elementsDOI 10.1101/2022.10.04.510636
Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer’s diseaseSemantic proximity
Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's diseaseSemantic proximity
Integrative single-nucleus multi-omics analysis prioritizes candidate <i>cis</i> and <i>trans</i> regulatory networks and their target genes in Alzheimer’s disease brainsSemantic proximity
Integrative single-nucleus multi-omics analysis prioritizes candidate cis and trans regulatory networks and their target genes in Alzheimer’s disease brainsSemantic proximity
Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortexSemantic proximity
Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex.Semantic proximity
Single-cell epigenomic identification of inherited risk loci in Alzheimer’s and Parkinson’s diseaseSemantic proximity
Epigenomic Profiling and Single-Nucleus-RNA-Seq Reveal <i>Cis</i> -Regulatory Elements in Human Retina, Macula and RPE and Non-Coding Genetic VariationSemantic proximity
A Single-cell and Spatial RNA-seq Database for Alzheimer’s Disease (ssREAD)Semantic proximity
Integrative analysis of single-nucleus RNA sequencing and Mendelian randomization to explore novel risk genes for Alzheimer's disease.Semantic proximity
Integrated Spatial and Single-Nuclei Transcriptomic Analysis of Long Non-Coding RNAs in Alzheimer’s DiseaseSemantic proximity
A comparative atlas of single-cell chromatin accessibility in the human brainSemantic proximity
Select a neighboring publication to make it the new centre.