Article

Cell type-specific histone acetylation profiling of Alzheimer’s Disease subjects and integration with genetics

2020-03-26

Abstract excerpt

We profile genome-wide histone 3 lysine 27 acetylation (H3K27ac) of 3 major brain cell types from hippocampus and dorsolateral prefrontal cortex (dlPFC) of subjects with and without Alzheimer’s Disease (AD). We confirm that single nucleotide polymorphisms (SNPs) associated with late onset AD (LOAD) prefer to reside in the microglial histone acetylome, which varies most strongly with age. We observe acetylation dif...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0b6296ab-0b55-52b7-83a3-28cb7fb1e18b
DOI: 10.1101/2020.03.26.010330

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell type-specific histone acetylation profiling of Alzheimer’s Disease subjects and integration with geneticsDOI 10.1101/2020.03.26.010330Read

Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with geneticsSemantic proximity Read

CHAS, a deconvolution tool, infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disordersSemantic proximity Read

A histone acetylome-wide association study of Alzheimer’s disease: neuropathology-associated regulatory variation in the human entorhinal cortexSemantic proximity Read

Single-cell epigenomic identification of inherited risk loci in Alzheimer’s and Parkinson’s diseaseSemantic proximity Read

Genomic partitioning of Alzheimer’s disease in humans reveals non-CNS etiologySemantic proximity Read

Genetics of the human microglia regulome refines Alzheimer’s disease risk lociSemantic proximity Read

Integration of Alzheimer’s disease genetics and myeloid genomics reveals novel disease risk mechanismsSemantic proximity Read

Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes.Semantic proximity Read

Cell type-specific associations with Alzheimer’s Disease conserved across racial and ethnic groupsSemantic proximity Read

A landscape of the genetic and cellular heterogeneity in Alzheimer diseaseSemantic proximity Read

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brainsSemantic proximity Read

A single cell brain atlas in human Alzheimer’s diseaseSemantic proximity Read