Article
Single-cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2R47H Alzheimer's risk gene mutation.
Molecular psychiatry - 1 Feb 2025
Johnston Kevin G, Berackey Bereket T, Tran Kristine M, Gelber Alon, Yu Zhaoxia, MacGregor Grant R, Mukamel Eran A, Tan Zhiqun, Green Kim N, Xu Xiangmin
Abstract excerpt
The R47H missense mutation of the TREM2 gene is a known risk factor for development of Alzheimer's Disease. In this study, we analyze the impact of the Trem2R47H mutation on specific cell types in multiple cortical and subcortical brain regions in the context of wild-type and 5xFAD mouse background. We profile 19 mouse brain sections consisting of wild-type, Trem2R47H, 5xFAD and Trem2R47H; 5xFAD genotypes using...
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