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Genomic partitioning of Alzheimer’s disease in humans reveals non-CNS etiology

2026-02-11

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is marked by hallmark neuropathological changes in the brain. However, its upstream genetic determinants, beyond the central nervous system (CNS), remain largely unexplored. To that extent, we integrated human genomic data with cross-tissue and single-cell analyses across up to 40 peripheral tissues and 100 brain regions. We observed limited genetic enrichment in the CNS...

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Literature Corpus work
160f91a6-35d6-57ab-a31e-55d5f71c8ca8
DOI
10.64898/2026.02.09.26344392
Open publication

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Genomic partitioning of Alzheimer’s disease in humans reveals non-CNS etiologyDOI 10.64898/2026.02.09.26344392
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