Article

The environment-sensing aryl-hydrocarbon receptor inhibits the chondrogenic fate of modulated smooth muscle cells in atherosclerotic lesions

2020-04-22

Abstract excerpt

<h4>Introduction</h4> Smooth muscle cells (SMC) play a critical role in atherosclerosis. The Aryl hydrocarbon receptor (AHR) is an environment-sensing transcription factor that contributes to vascular development, and has been implicated in coronary artery disease (CAD) risk. We hypothesized that AHR can affect atherosclerosis by regulating phenotypic modulation of SMC. <h4>Methods</h4> We combined RNA-Seq, ChIP...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ed2fa928-5440-50d5-92b4-3414428dd404
DOI: 10.1101/2020.04.21.049890

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The environment-sensing aryl-hydrocarbon receptor inhibits the chondrogenic fate of modulated smooth muscle cells in atherosclerotic lesionsDOI 10.1101/2020.04.21.049890Read

Aryl-hydrocarbon receptor in smooth muscle cells protect against dioxin induced adverse remodeling of atherosclerosisSemantic proximity Read

Retinoic acid signaling modulates smooth muscle cell phenotypic switching in atherosclerosis through epigenetic regulation of gene expressionSemantic proximity Read

Atherosclerosis is a smooth muscle cell-driven tumor-like diseaseSemantic proximity Read

Comprehensive Multimodal Profiling of Atherosclerosis Reveals Bhlhe40 as a Potential Regulator of Vascular Smooth Muscle Cell Phenotypic ModulationSemantic proximity Read

Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis.Semantic proximity Read

Dual Lineage Tracing Identifies Cellular Mechanisms Underlying Radiation-Associated Changes in Atherosclerotic Lesion CompositionSemantic proximity Read

The Greatly Under-Represented Role of Smooth Muscle Cells in AtherosclerosisSemantic proximity Read

Smad3 Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic PlaqueSemantic proximity Read

Modulated smooth muscle cells accumulate late in human coronary atherosclerosis and are temporally and spatially linked to necrotic core formationSemantic proximity Read

Mapping atherogenesis mechanisms in smooth muscle cells by targeting genes linked to coronary artery diseaseSemantic proximity Read

<i>Smad3</i> Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic PlaqueSemantic proximity Read

Molecular and spatiotemporal characterization of cells in murine atherosclerotic plaquesSemantic proximity Read