Article

Comprehensive Multimodal Profiling of Atherosclerosis Reveals Bhlhe40 as a Potential Regulator of Vascular Smooth Muscle Cell Phenotypic Modulation

2025-05-23

Abstract excerpt

<h4>Background</h4> Vascular smooth muscle cells (VSMCs) play a central role in atherosclerosis by undergoing phenotypic modulation from a quiescent, contractile state to a range of synthetic phenotypes, including fibroblast-like, macrophage-like, and lipid-laden foam cell–like states. However, a comprehensive multimodal characterization and understanding of the transcriptional programs driving these transitions...

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Literature Corpus work: 6a61c0f1-cee7-550c-944d-184a1d80f023
DOI: 10.1101/2025.05.20.655228

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