Article

Mapping atherogenesis mechanisms in smooth muscle cells by targeting genes linked to coronary artery disease

2024-11-12

Abstract excerpt

Recent genome-wide association studies (GWAS) have identified multiple vascular cell-expressed genes linked to coronary artery disease (CAD), suggesting that smooth muscle cells (SMCs) and SMC-derived metaplastic cells are promising targets for novel antiatherosclerosis therapies. However, the disease-promoting pathways of most GWAS-identified genes are unknown, hindering their translation into therapeutic targets...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68be99e9-a80e-56e2-8c07-1308391e09e0
DOI: 10.1101/2024.11.11.623011

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mapping atherogenesis mechanisms in smooth muscle cells by targeting genes linked to coronary artery diseaseDOI 10.1101/2024.11.11.623011Read

Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci.Semantic proximity Read

Genetic regulatory mechanisms of smooth muscle cells map to coronary artery disease risk lociSemantic proximity Read

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosisSemantic proximity Read

Transcriptomic, Specific Marker, and Pathway Analysis of Smooth Muscle Cell Foam Cells Relative to Macrophage Foam Cells in Human AtherosclerosisSemantic proximity Read

Smad3 Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic PlaqueSemantic proximity Read

Genetic regulation of human aortic smooth muscle cell gene expression and splicing predict causal coronary artery disease genesSemantic proximity Read

Female gene networks are expressed in myofibroblast-like smooth muscle cells in vulnerable atherosclerotic plaquesSemantic proximity Read

Smooth muscle cell phenotypic modulation during atherosclerosis.Semantic proximity Read

<i>Smad3</i> Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic PlaqueSemantic proximity Read

Comprehensive identification of coronary artery disease-associated variants regulating vascular smooth muscle cell gene expressionSemantic proximity Read

Single-Cell RNA-Seq Reveals Adventitial Fibroblast Alterations during Mouse AtherosclerosisSemantic proximity Read

Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells.Semantic proximity Read