Article

Retinoic acid signaling modulates smooth muscle cell phenotypic switching in atherosclerosis through epigenetic regulation of gene expression

2022-11-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Smooth muscle cells (SMCs) substantially contribute to the development of atherosclerosis through a process called “phenotypic switching.” Our previous work identified an SMC-derived intermediate cell type, termed “SEM” cells, which plays a crucial role in SMC transition to other cell types and in lesion development. Activation of retinoic acid (RA) signaling by all-trans re...

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Literature Corpus work: 90738e1a-28f3-598c-8ef7-c8b9d92ed729
DOI: 10.1101/2022.11.09.515888

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