Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis.

doi:10.1161/CIRCULATIONAHA.120.046672

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Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis.

Circulation - 24 Nov 2020

Alencar Gabriel F, Owsiany Katherine M, Karnewar Santosh, Sukhavasi Katyayani, Mocci Giuseppe, Nguyen Anh T, Williams Corey M, Shamsuzzaman Sohel, Mokry Michal, Henderson Christopher A, Haskins Ryan, Baylis Richard A, Finn Aloke V, McNamara Coleen A, Zunder Eli R, Venkata Vamsidhar, Pasterkamp Gerard, Björkegren Johan, Bekiranov Stefan, Owens Gary K

Abstract excerpt

BACKGROUND: Rupture and erosion of advanced atherosclerotic lesions with a resultant myocardial infarction or stroke are the leading worldwide cause of death. However, we have a limited understanding of the identity, origin, and function of many cells that make up late-stage atherosclerotic lesions, as well as the mechanisms by which they control plaque stability. METHODS: We conducted a comprehensive single-cell...

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PMID: 32674599
DOI: 10.1161/CIRCULATIONAHA.120.046672
PMCID: PMC7682794

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