Article

<i>Smad3</i> Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic Plaque

2020-09-16

Abstract excerpt

Atherosclerotic plaques consist mostly of smooth muscle cells (SMC), and genes that influence SMC biology can modulate coronary artery disease (CAD) risk. Allelic variation at 15q22.33 has been identified by genome-wide association studies to modify the risk of CAD, and is associated with expression of SMAD3 in SMC, but the mechanism by which this gene modifies CAD risk remains poorly understood. SMC-specific del...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 660be3aa-763c-54f3-9693-fed1f2cdf6f1
DOI: 10.1101/2020.09.15.299131

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Smad3</i> Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic PlaqueDOI 10.1101/2020.09.15.299131Read

Smad3 Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic PlaqueSemantic proximity Read

Smad3 regulates smooth muscle cell fate and mediates adverse remodeling and calcification of the atherosclerotic plaqueSemantic proximity Read

Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis.Semantic proximity Read

Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease riskSemantic proximity Read

PRDM16 controls smooth muscle cell fate in atherosclerosisSemantic proximity Read

Coronary Artery Disease Risk Gene <i>PRDM16</i> is Preferentially Expressed in Vascular Smooth Muscle Cells and a Potential Novel Regulator of Smooth Muscle HomeostasisSemantic proximity Read

Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human.Semantic proximity Read

Coronary artery disease risk gene PRDM16 regulates smooth muscle homeostasis.Semantic proximity Read

hiPSC Modeling of Lineage-Specific Smooth Muscle Cell Defects Caused by TGFBR1 A230T Variant, and Its Therapeutic Implications for Loeys-Dietz SyndromeSemantic proximity Read

The 9p21.3 coronary artery disease risk locus drives vascular smooth muscle cells to an osteochondrogenic stateSemantic proximity Read

Smooth muscle cell phenotypic modulation during atherosclerosis.Semantic proximity Read

Mapping atherogenesis mechanisms in smooth muscle cells by targeting genes linked to coronary artery diseaseSemantic proximity Read