Article

Smad3 Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic Plaque

2021-07-19

Abstract excerpt

<title>Abstract</title> <p>Atherosclerotic plaques consist mostly of smooth muscle cells (SMC), and genes that influence SMC biology can modulate coronary artery disease (CAD) risk. Allelic variation at 15q22.33 has been identified by genome-wide association studies to modify the risk of CAD, and is associated with expression of <italic>SMAD3</italic> in SMC, but the mechanism by which this gene modifies CAD risk...

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Literature Corpus work: 6a90895c-8f81-5d8a-9383-651263949551
DOI: 10.21203/rs.3.rs-708882/v1

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