Article

Modulated smooth muscle cells accumulate late in human coronary atherosclerosis and are temporally and spatially linked to necrotic core formation

2025-02-20

Abstract excerpt

<h4>Background and Aims</h4> Proliferation of arterial smooth muscle cells (SMCs) and their modulation to alternative mesenchymal phenotypes is a central mechanism in the growth of atherosclerotic lesions. The underlying processes have been studied extensively in mouse models, but a detailed analysis of when and where modulated SMCs accumulate in human atherosclerosis is lacking. The present study mapped modulate...

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Literature Corpus work: c7403e4e-5c57-59f2-9ace-c8d3c164bcb1
DOI: 10.1101/2025.02.18.25322466

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