Article

CRISPRi perturbation screens and eQTLs provide complementary and distinct insights into GWAS target genes

2025-05-06

Abstract excerpt

Most genetic variants associated with human traits and diseases lie in noncoding regions of the genome 1 , and a key challenge is determining which genes they affect 2,3 . A common approach has been to leverage associations between natural genetic variation and gene expression to identify expression quantitative trait loci (eQTLs) in the population 4,5 . At the same time, a novel approach uses pooled CRISPR int...

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Literature Corpus work: ec71228a-c418-5936-835a-0a66eba288ed
DOI: 10.1101/2025.05.05.651929

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