Article

crisprQTL mapping as a genome-wide association framework for cellular genetic screens

2018-05-04

Abstract excerpt

Expression quantitative trait locus (eQTL) and genome-wide association studies (GWAS) are powerful paradigms for mapping the determinants of gene expression and organismal phenotypes, respectively. However, eQTL mapping and GWAS are limited in scope (to naturally occurring, common genetic variants) and resolution (by linkage disequilibrium). Here, we present crisprQTL mapping, a framework in which large numbers of...

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Literature Corpus work: 101b105e-4ac3-5c52-9ac7-b8db85ed4584
DOI: 10.1101/314344

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