Article

Defining the function of disease variants with CRISPR editing and multimodal single cell sequencing

2024-03-29

Abstract excerpt

<h4>Abstract / Summary Paragraph</h4> Genetic studies have identified thousands of individual disease-associated non-coding alleles, but identification of the causal alleles and their functions remain critical bottlenecks. Even though CRISPR-Cas editing has enabled targeted modification of DNA, inefficient editing leads to heterogeneous outcomes across individual cells, limiting the ability to detect functional c...

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Literature Corpus work: 3a382d30-30e2-5566-af4a-b4214d2928ba
DOI: 10.1101/2024.03.28.587175

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