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Mapping the functional impact of non-coding regulatory elements in primary T cells through single-cell CRISPR screens.

Genome biology - 2 Feb 2024

Alda-Catalinas Celia, Ibarra-Soria Ximena, Flouri Christina, Gordillo Jorge Esparza, Cousminer Diana, Hutchinson Anna, Sun Bin, Pembroke William, Ullrich Sebastian, Krejci Adam, Cortes Adrian, Acevedo Alison, Malla Sunir, Fishwick Carl, Drewes Gerard, Rapiteanu Radu

Abstract excerpt

BACKGROUND: Drug targets with genetic evidence are expected to increase clinical success by at least twofold. Yet, translating disease-associated genetic variants into functional knowledge remains a fundamental challenge of drug discovery. A key issue is that the vast majority of complex disease associations cannot be cleanly mapped to a gene. Immune disease-associated variants are enriched within regulatory...

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Identifiers

PMID: 38308274
DOI: 10.1186/s13059-024-03176-z
PMCID: PMC10835965

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