Article

Endogenous fine-mapping of functional regulatory elements in complex genetic loci

2023-05-08

Abstract excerpt

The vast majority of genetic loci associated with polygenic complex traits are located in non-coding regions of the human genome. However, many of these regions exhibit high- order gene regulatory relationships and complicated linkage disequilibrium (LD) configurations, which bring challenges to accurately identify causal variants and their target genes controlling specific molecular processes or traits. We employ...

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Literature Corpus work: 1f0cf7ed-c10d-533a-acda-67f02b56fb6b
DOI: 10.1101/2023.05.06.539696

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