Article

Discovery of target genes and pathways of blood trait loci using pooled CRISPR screens and single cell RNA sequencing

2021-04-08

Abstract excerpt

The majority of variants associated with complex traits and common diseases identified by genome-wide association studies (GWAS) map to noncoding regions of the genome with unknown regulatory effects in cis and trans . By leveraging biobank-scale GWAS data, massively parallel CRISPR screens and single cell transcriptome sequencing, we discovered target genes of noncoding variants for blood trait loci. The closes...

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Literature Corpus work: 0f7ca351-6976-5f95-be39-6f4bdf91b6bb
DOI: 10.1101/2021.04.07.438882

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