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A genome-scale single cell CRISPRi map of <i>trans</i> gene regulation across human pluripotent stem cell lines

2024-11-28

Abstract excerpt

Population-scale resources of genetic, molecular, and cellular information form the basis for understanding human genomes, charting the heritable basis of disease, and tracing the effects of mutations. Pooled perturbation assays applied to cellular models, probing the effect of many perturbations coupled with an scRNA-seq readout (Perturb-seq), are especially potent references for interpreting disease-linked mutat...

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Literature Corpus work
280928aa-22e1-5eb1-acf8-675d1737a55f
DOI
10.1101/2024.11.28.625833
Open publication

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A genome-scale single cell CRISPRi map of <i>trans</i> gene regulation across human pluripotent stem cell linesDOI 10.1101/2024.11.28.625833
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