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Article

Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens.

Science (New York, N.Y.) - 19 May 2023

Morris John A, Caragine Christina, Daniloski Zharko, Domingo Júlia, Barry Timothy, Lu Lu, Davis Kyrie, Ziosi Marcello, Glinos Dafni A, Hao Stephanie, Mimitou Eleni P, Smibert Peter, Roeder Kathryn, Katsevich Eugene, Lappalainen Tuuli, Sanjana Neville E

Abstract excerpt

Most variants associated with complex traits and diseases identified by genome-wide association studies (GWAS) map to noncoding regions of the genome with unknown effects. Using ancestrally diverse, biobank-scale GWAS data, massively parallel CRISPR screens, and single-cell transcriptomic and proteomic sequencing, we discovered 124 cis-target genes of 91 noncoding blood trait GWAS loci. Using precise variant...

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Identifiers

PMID: 37141313
DOI: 10.1126/science.adh7699
PMCID: PMC10518238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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