Article

Mapping the functional impact of non-coding regulatory elements in primary T cells through single-cell CRISPR screens

2023-05-14

Abstract excerpt

Drug targets with human genetic evidence are expected to increase clinical success by at least two-fold. Yet, translating disease-associated genetic variants into functional knowledge remains a fundamental challenge of early drug discovery. A key issue is that, currently, the vast majority of complex disease associations cannot be cleanly mapped to a gene. Immune disease-associated variants are enriched within reg...

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Literature Corpus work: 2f5e131f-15e0-5b6d-9b7e-d4bb6eed9985
DOI: 10.1101/2023.05.14.540711

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