Article

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes

2024-09-09

Abstract excerpt

Most phenotype-associated genetic variants map to non-coding regulatory regions of the human genome. Moreover, variants associated with blood cell phenotypes are enriched in regulatory regions active during hematopoiesis. To systematically explore the nature of these regions, we developed a highly efficient strategy, Perturb-multiome, that makes it possible to simultaneously profile both chromatin accessibility an...

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Literature Corpus work: 39cfefbc-4f1a-525c-baff-13fd5a0dcd8f
DOI: 10.1101/2024.09.09.611392

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