Article

A divergent mutational and clonal landscape in aged HSCs is not linked to aging-associated clonal hematopoiesis

2026-01-26

Abstract excerpt

Somatic mutations accumulate throughout life and can serve as endogenous markers to trace cellular lineage relationships. In hematopoietic stem cells (HSCs), aging is associated with functional decline and clonal skewing, yet how somatic mutational histories shape clonal architecture at single-cell resolution remains incompletely understood. Here, we leverage single-cell RNA sequencing from murine and human long-t...

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Literature Corpus work: eb4a9b59-d7b9-5f29-9beb-a932d505e363
DOI: 10.64898/2026.01.24.701060

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