Article

Mitochondrial variant enrichment from high-throughput single-cell RNA-seq resolves clonal populations

2021-03-09

Abstract excerpt

Reconstructing lineage relationships in complex tissues can reveal mechanisms underlying development and disease. Recent methods combine single-cell transcriptomics with mitochondrial DNA variant detection to establish lineage relationships in primary human cells, but are not scalable to interrogate complex tissues. To overcome this limitation, here we develop a technology for high-confidence detection of mitochon...

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Literature Corpus work: 995f83ed-32db-5e99-83fc-921dc13d6fb8
DOI: 10.1101/2021.03.08.434450

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