Clonal tracing with somatic epimutations reveals dynamics of blood ageing.

doi:10.1038/s41586-025-09041-8

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Article

Clonal tracing with somatic epimutations reveals dynamics of blood ageing.

Nature - 1 Jul 2025

Scherer Michael, Singh Indranil, Braun Martina Maria, Szu-Tu Chelsea, Sanchez Sanchez Pedro, Lindenhofer Dominik, Jakobsen Niels Asger, Körber Verena, Kardorff Michael, Nitsch Lena, Kautz Pauline, Rühle Julia, Bianchi Agostina, Cozzuto Luca, Frömel Robert, Beneyto-Calabuig Sergi, Lareau Caleb, Satpathy Ansuman T, Beekman Renée, Steinmetz Lars M, Raffel Simon, Ludwig Leif S, Vyas Paresh, Rodriguez-Fraticelli Alejo, Velten Lars

Abstract excerpt

Current approaches used to track stem cell clones through differentiation require genetic engineering1,2 or rely on sparse somatic DNA variants3,4, which limits their wide application. Here we discover that DNA methylation of a subset of CpG sites reflects cellular differentiation, whereas another subset undergoes stochastic epimutations and can serve as digital barcodes of clonal identity. We demonstrate that...

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PMID: 40399669
DOI: 10.1038/s41586-025-09041-8
PMCID: PMC12240852

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