Article

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation

2025-03-26

Abstract excerpt

Somatic mutations that increase hematopoietic stem cell (HSC) fitness drive their expansion in clonal hematopoiesis (CH) and predispose to blood cancers. Although CH frequently occurs with aging, it rarely progresses to overt malignancy. Population variation in the growth rate and potential of mutant clones suggests the presence of genetic factors protecting against CH, but these remain largely undefined. Here, we...

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Literature Corpus work: 02058a8f-919a-5e1d-b3e2-89b7e18ccaa2
DOI: 10.1101/2025.03.24.645017

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