Article

Genomic and phenomic landscape of clonal hematopoiesis in over a million ancestrally diverse participants

2022-07-31

Abstract excerpt

With aging, somatic mutations in hematopoietic stem and progenitor cells (HSPC) can give rise to clonal hematopoiesis of indeterminate potential (CHIP), a premalignant state associated with diverse age-related diseases. Here we report the largest multi-ancestry genome-wide analysis of CHIP to date (N = 1,018,305), including individuals of African (N = 85,978), Admixed American (N = 191,371), East Asian (N = 13,532...

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Literature Corpus work: a0e12480-12b3-572f-a861-6d6d36768d1a
DOI: 10.1101/2022.07.29.22278015

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