Article

Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespan

2024-04-01

Abstract excerpt

<h4>Summary</h4> Current approaches to lineage tracing of stem cell clones require genetic engineering or rely on sparse somatic DNA variants, which are difficult to capture at single-cell resolution. Here, we show that targeted single-cell measurements of DNA methylation at single-CpG resolution deliver joint information about cellular differentiation state and clonal identities. We develop EPI-clone, a droplet-...

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Literature Corpus work: 77eccf05-93b2-58d4-8b48-5afb7f0e3eee
DOI: 10.1101/2024.04.01.587514

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