Article
Deciphering cell states and genealogies of human haematopoiesis.
Nature - 1 Mar 2024
Weng Chen, Yu Fulong, Yang Dian, Poeschla Michael, Liggett L Alexander, Jones Matthew G, Qiu Xiaojie, Wahlster Lara, Caulier Alexis, Hussmann Jeffrey A, Schnell Alexandra, Yost Kathryn E, Koblan Luke W, Martin-Rufino Jorge D, Min Joseph, Hammond Alessandro, Ssozi Daniel, Bueno Raphael, Mallidi Hari, Kreso Antonia, Escabi Javier, Rideout William M, Jacks Tyler, Hormoz Sahand, van Galen Peter, Weissman Jonathan S, Sankaran Vijay G
Abstract excerpt
The human blood system is maintained through the differentiation and massive amplification of a limited number of long-lived haematopoietic stem cells (HSCs)1. Perturbations to this process underlie diverse diseases, but the clonal contributions to human haematopoiesis and how this changes with age remain incompletely understood. Although recent insights have emerged from barcoding studies in model systems2-5,...
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