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Article

Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis.

Nature communications - 9 Sept 2024

Uddin Md Mesbah, Saadatagah Seyedmohammad, Niroula Abhishek, Yu Bing, Hornsby Whitney E, Ganesh Shriienidhie, Lannery Kim, Schuermans Art, Honigberg Michael C, Bick Alexander G, Libby Peter, Ebert Benjamin L, Ballantyne Christie M, Natarajan Pradeep

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is linked to diverse aging-related diseases, including hematologic malignancy and atherosclerotic cardiovascular disease (ASCVD). While CHIP is common among older adults, the underlying factors driving its development are largely unknown. To address this, we performed whole-exome sequencing on 8,374 blood DNA samples collected from 4,187 Atherosclerosis Risk...

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Source

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Identifiers

PMID: 39251642
DOI: 10.1038/s41467-024-52302-9
PMCID: PMC11385577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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