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Article

Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing.

PLoS genetics - 1 Jul 2014

Hughes Andrew E O, Magrini Vincent, Demeter Ryan, Miller Christopher A, Fulton Robert, Fulton Lucinda L, Eades William C, Elliott Kevin, Heath Sharon, Westervelt Peter, Ding Li, Conrad Donald F, White Brian S, Shao Jin, Link Daniel C, DiPersio John F, Mardis Elaine R, Wilson Richard K, Ley Timothy J, Walter Matthew J, Graubert Timothy A

Abstract excerpt

Next-generation sequencing has been used to infer the clonality of heterogeneous tumor samples. These analyses yield specific predictions-the population frequency of individual clones, their genetic composition, and their evolutionary relationships-which we set out to test by sequencing individua...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to High-Throughput Nucleotide Sequencing

Share to Leukemia, Myeloid, Acute

Share to Myelodysplastic Syndromes

Share to Neoplasm Recurrence, Local

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Source

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Identifiers

PMID: 25010716
DOI: 10.1371/journal.pgen.1004462
PMCID: PMC4091781

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25010716-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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