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Transcriptional heterogeneity predicts and enables clonal selection in ageing haematopoiesis

2026-06-25

Abstract excerpt

<title>Abstract</title> <p>A general puzzle in stem-cell and ageing biology is why a few cellular clones come to dominate an ageing tissue while otherwise similar neighbours do not, a fate that the average transcriptional state of a cell predicts poorly. Here we ask whether the variability between sister cells of a clone, rather than their transcriptional state, is the property that predicts ageing-associated clo...

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Literature Corpus work
614af9ff-01d2-56f4-b4cd-458decc664c9
DOI
10.21203/rs.3.rs-10046174/v1
Open publication

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Transcriptional heterogeneity predicts and enables clonal selection in ageing haematopoiesisDOI 10.21203/rs.3.rs-10046174/v1
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