Article

Large-scale single-cell phylogenetic mapping of clonal evolution in the human aging esophagus

2025-10-13

Abstract excerpt

The human somatic genome evolves throughout our lifespan, producing mosaic individuals comprising clones harboring different mutations across tissues. While clonal expansions in the hematopoietic system have been extensively characterized and reported to be nearly ubiquitous, clonal mosaicism (CM) has more recently also been described across multiple solid tissues. However, outstanding questions remain about the p...

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Literature Corpus work: 5f2e462e-fb55-557e-9444-2d056a3fc581
DOI: 10.1101/2025.10.11.681805

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