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Article

Clonal dynamics of haematopoiesis across the human lifespan

1 Jun 2022

Abstract excerpt

, but the reason for such abrupt functional decline after 70 years of age remains unclear. Here we sequenced 3,579 genomes from single cell-derived colonies of haematopoietic cells across 10 human subjects from 0 to 81 years of age. Haematopoietic stem cells or multipotent progenitors (HSC/MPPs) accumulated a mean of 17 mutations per year after birth and lost 30 base pairs per year of telomere length....

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PMID: 35650442
DOI: 10.1038/s41586-022-04786-y

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