Article

Modeling mitochondrial inheritance enables high-precision single-cell lineage tracing in humans

2026-02-13

Abstract excerpt

Somatic mutations in mitochondrial DNA (mtDNA) provide natural barcodes that enable engineering-free lineage tracing in human tissues, but the complex dynamics of mtDNA inheritance across cell divisions and incomplete sampling of mtDNA introduce uncertainty in reconstructed lineages. Here, we present MitoDrift, a probabilistic framework that integrates Wright-Fisher drift dynamics with sparse single-cell measureme...

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Literature Corpus work: 803c41b0-5cd2-5b2d-9ef9-657b58732ed6
DOI: 10.64898/2026.02.12.705660

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