Article

Tracking tau and cellular responses in human iPSC-microglia from uptake to seedable secretion in extracellular vesicles

2025-07-21

Abstract excerpt

The templated spread of tau aggregates in tauopathies has been attributed to neuron-to- neuron spread, but microglia have also been implicated through mouse studies. Here we examine in detail the uptake, processing, release and seeding of tau using human iPS- derived microglia (iMGL). We show that tau is taken up by iMGL via LRP1 and heparan sulfate proteoglycans, with a role for LRRK2 in LRP1 trafficking, and tha...

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Literature Corpus work: eab5df03-61b1-5f34-b632-a22ef5fd52ff
DOI: 10.1101/2025.07.17.664991

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