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P2RX7 regulates tauopathy progression via tau and mitochondria loading in extracellular vesicles

2025-06-23

Abstract excerpt

<title>Abstract</title> <p>P2x purinoreceptor 7 (P2RX7), an ATP-gated ion channel, is known to play pivotal roles in the progression of Alzheimer’s disease (AD), although its cell type-specific pathological mechanisms have yet to be elucidated. Here, we show that genetic deletion of P2rx7 mitigates brain atrophy, tau accumulation and cognitive impairment in PS19 tauopathy mice. Specific deletion of P2rx7 in micro...

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Literature Corpus work
2d19bdd6-7c52-567c-bafb-0f174841ee29
DOI
10.21203/rs.3.rs-6771517/v1
Open publication

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P2RX7 regulates tauopathy progression via tau and mitochondria loading in extracellular vesiclesDOI 10.21203/rs.3.rs-6771517/v1
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