Article

Whole genome CRISPR screens identify a LRRK2-regulated pathway for extracellular tau uptake by human neurons

2020-08-11

Abstract excerpt

Extracellular release and cellular uptake of pathogenic forms of the microtubule-associated protein tau contribute to the pathogenesis of several neurodegenerative diseases, including Alzheimer’s disease. Defining the cellular mechanisms and pathways for tau entry to human neurons is essential to understanding tauopathy pathogenesis and the rational design of disease-modifying therapeutics. Whole genome CRISPR los...

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Literature Corpus work: aab903db-79bd-5c36-bee8-9a46398d37d4
DOI: 10.1101/2020.08.11.246363

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