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Article

P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice.

Molecular neurodegeneration - 18 Aug 2020

Ruan Zhi, Delpech Jean-Christophe, Venkatesan Kalavai Srinidhi, Van Enoo Alicia A, Hu Jianqiao, Ikezu Seiko, Ikezu Tsuneya

Abstract excerpt

BACKGROUND: Neuronal accumulation of misfolded microtubule-associated protein tau is a hallmark of neuropathology in Alzheimer's disease, frontotemporal dementia, and other tauopathies, and has been a therapeutic target. Microglia can spread tau pathology by secreting tau-containing exosomes, although the specific molecular target is yet to be identified for the therapeutic intervention. P2X purinoceptor 7...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Purinergic P2X7

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Source

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Identifiers

PMID: 32811520
DOI: 10.1186/s13024-020-00396-2
PMCID: PMC7436984

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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