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Article

Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau.

Molecular psychiatry - 1 Oct 2025

Iyer Abhirami K, Vermunt Lisa, Mirfakhar Farzaneh S, Minaya Miguel, Acquarone Mariana, Koppisetti Rama Krishna, Renganathan Arun, You Shih-Feng, Danhash Emma P, Schache Kylie J, Verbeck Anthony, Galasso Grant, Lee Scott M, Huang Guangming, Miller Katherine J, Marsh Jacob, Nana Alissa L, Spina Salvatore, Seeley William W, Grinberg Lea T, Temple Sally, Teunissen Charlotte E, Sato Chihiro, Karch Celeste M

Abstract excerpt

Neuronal dysfunction has been extensively studied as a central feature of neurodegenerative tauopathies. However, across neurodegenerative diseases, there is strong evidence for active involvement of immune cells like microglia in driving disease pathophysiology. Here, we demonstrate that MAPT mRNA and tau protein are expressed in microglia in human brains and in human induced pluripotent stem cell (iPSC)-derived...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40527900
DOI: 10.1038/s41380-025-03073-2
PMCID: PMC12436154

Genes

MAPT
TREM2
TYROBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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