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Article

Glial control of extracellular α-synuclein propagation in LRRK2 Parkinson's disease.

Advances in immunology - 1 Jan 2026

Datta Indrani, Sahu Dibyam Debasish

Abstract excerpt

Parkinson's disease (PD) pathology extends well beyond dopaminergic neuronal loss, with glial cells-microglia and astrocytes-emerging as active architects of α-synuclein spread rather than passive bystanders. This review synthesises current evidence on how mutations in Leucine-Rich Repeat Kinase 2 (LRRK2), the most common genetic cause of familial PD, fundamentally corrupt glial handling of extracellular...

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Source

Identifiers

PMID: 42629126
DOI: 10.1016/bs.ai.2026.04.005

Genes

NLRP3
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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