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Article

The Fate of Tau Aggregates Between Clearance and Transmission

18 Jul 2022

Abstract excerpt

Neuronal accumulation of mis-folded tau is the pathological hallmark of multiple neurodegenerative disorders, including Alzheimer's disease. Distinct from amyloid plaques, which appear simultaneously throughout the brain, tau pathology develops first in a specific brain region and then propagates to neuroanatomically connected brain regions, exacerbating the disease. Due to the implication in disease progression,...

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Identifiers

PMID: 35923541
DOI: 10.3389/fnagi.2022.932541

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