Article

Cellular and molecular phenotypes of <i>C9orf72</i> ALS/FTD patient derived iPSC-microglia mono-cultures

2020-09-03

Abstract excerpt

<h4>Summary</h4> While motor and cortical neurons are affected in C9orf72 ALS/FTD, it remains still largely unknown if and how non-neuronal cells induce or exacerbate neuronal damage. We generated C9orf72 ALS/FTD patient-derived induced pluripotent stem cells differentiated into microglia (iPSC-MG) and examined their intrinsic phenotypes. Similar to iPSC motor neurons, C9orf72 ALS/FTD iPSC-MG mono-cultures for...

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Literature Corpus work: 20bd38e5-558d-534a-a9c7-eae53e9a100f
DOI: 10.1101/2020.09.03.277459

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