Article

MAPT regulates autophagic-lysosomal function and phagocytosis in human microglia

2026-09-01

Abstract excerpt

Tauopathies are characterized by the accumulation and spread of pathogenic tau aggregates throughout the brain, a process that is increasingly recognized to involve not only neurons but also microglia. However, whether pathogenic MAPT directly alters microglial degradative capacity remains poorly understood. Here, using isogenic human induced pluripotent stem cell-derived microglia carrying the pathogenic MAPT IVS...

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Literature Corpus work: b29e589e-3eb9-5224-82b0-35bd0a6a64d0
DOI: 10.64898/2026.08.27.747662

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