Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fate and propagation of endogenously formed Tau aggregates in neuronal cells

12 Nov 2020

Abstract excerpt

Tau accumulation in the form of neurofibrillary tangles in the brain is a hallmark of tauopathies such as Alzheimer's disease (AD). Tau aggregates accumulate in brain regions in a defined spatiotemporal pattern and may induce the aggregation of native Tau in a prion-like manner. However, the underlying mechanisms of cell-to-cell spreading of Tau pathology are unknown and could involve encapsulation within...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Neuroscience and Neuropharmacology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33179866
DOI: 10.15252/emmm.202012025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fate and propagation of endogenously formed Tau aggregates in neuronal cellsPMID 33179866Read ↗

Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein PathologySemantic proximity Read ↗

The Fate of Tau Aggregates Between Clearance and TransmissionSemantic proximity Read ↗

Tracking tau and cellular responses in human iPSC-microglia from uptake to seedable secretion in extracellular vesiclesSemantic proximity Read ↗

Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice.Semantic proximity Read ↗

Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau.Semantic proximity Read ↗

Interneuronal transfer of human tau between Lamprey central neurons in situ.Semantic proximity Read ↗

Proteins Recruited to Exosomes by Tau Overexpression Implicate Novel Cellular Mechanisms Linking Tau Secretion with Alzheimer's DiseaseSemantic proximity Read ↗

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregationSemantic proximity Read ↗

Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubesSemantic proximity Read ↗

Visualization of prion-like transfer in Huntington's disease models.Semantic proximity Read ↗

Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of TauopathySemantic proximity Read ↗

Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.