Article

Microglia become hypofunctional and release metalloproteases and tau seeds after phagocytosing live neurons with P301S tau aggregates

2021-02-26

Abstract excerpt

The microtubule-associated protein tau aggregates in multiple neurodegenerative diseases, causing inflammation and changing the inflammatory signature of microglia by unknown mechanisms. We have shown that microglia phagocytose live neurons containing tau aggregates cultured from P301S tau transgenic mice due to neuronal tau aggregate-induced exposure of the ‘eat me’ signal phosphatidylserine. Here we show that af...

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Literature Corpus work: 11f8fa0a-f3da-5c2b-b537-766a789ec6cb
DOI: 10.1101/2021.02.26.433088

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