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Cell autonomous microglia defects in a stem cell model of frontotemporal dementia

2024-05-16

Abstract excerpt

Neuronal dysfunction has been extensively studied as a central feature of neurodegenerative tauopathies. However, across neurodegenerative diseases, there is strong evidence for active involvement of immune cells like microglia in driving disease pathophysiology. Here, we demonstrate that tau mRNA and protein are expressed in microglia in human brains and in human induced pluripotent stem cell (iPSC)-derived micro...

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Literature Corpus work
b6093de1-4617-56c4-a116-4d037587996b
DOI
10.1101/2024.05.15.24307444
Open publication

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Cell autonomous microglia defects in a stem cell model of frontotemporal dementiaDOI 10.1101/2024.05.15.24307444
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