Article

Bidirectional modulation of aging-associated cellular phenotypes by mitochondrial genome replacement

2026-06-30

Abstract excerpt

Mitochondrial dysfunction is a hallmark of cellular aging, but whether age-associated cellular decline can be functionally reversed remains unclear. Here, we applied mitochondrial genome replacement to replicative senescent fibroblasts and aged T cells derived from mice and humans. In senescent fibroblasts, replacement with mitochondria from young cells extended proliferative lifespan, whereas replacement with age...

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Literature Corpus work: ea72354a-41ef-5c51-9556-f58cb1186b6e
DOI: 10.64898/2026.06.26.734763

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