The miR-30-5p/TIA-1 axis directs cellular senescence by regulating mitochondrial dynamics

Abstract excerpt

Senescent cells exhibit a diverse spectrum of changes in their morphology, proliferative capacity, senescence-associated secretory phenotype (SASP) production, and mitochondrial homeostasis. These cells often manifest with elongated mitochondria, a hallmark of cellular senescence. However, the precise regulatory mechanisms orchestrating this phenomenon remain predominantly unexplored. In this study, we provide...

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• interferon and immune responses
• MicroRNA in disease regulation
• Telomeres, Telomerase, and Senescence